Journal: PLoS ONE
Article Title: Periostin Links Mechanical Strain to Inflammation in Abdominal Aortic Aneurysm
doi: 10.1371/journal.pone.0079753
Figure Lengend Snippet: A-B : Gelfoam patches containing PBS (Control, n = 6) or recombinant periostin (rPeriostin, n = 7) were placed into periaortic spaces of mice for 7 days. Representative images show mouse aortic walls, stained with hematoxylin/eosin (HE) or with antibodies against periostin, phosphorylated FAK (pFAK), or MCP-1 ( A ). Infiltrating cells were counted in 5-10 high-power fields ( B ). Data are mean ± SE. * p <0.05 compared to Control. C : Schematic diagram represents the proposed vicious cycle of periostin upregulation driven by mechanical strain through activation of FAK, resulting in the maintenance of inflammation in AAA.
Article Snippet: In the other study, we placed Gelfoam patches (3.5×2×2 mm) (Pfizer, New York, NY, USA) that contained 15 μg of recombinant mouse periostin (R&D Systems) in the periaortic space of mice for 7 days.
Techniques: Control, Recombinant, Staining, Activation Assay